Abstract: Objective To investigate the significance of rheumatoid arthritis (RA) related animal models for researching pathogenesis, influencing factors and treatment of RA. Method We established the CIA and AA rat models of RA to analyse their model stability and repeatability. In addition, we also treated rats in these two model groups with methotrexate and laflumeter to evaluate the drug efficacy evaluating ability of CIA and AA rat models. Result The membrane formation rate of CIA model was earlier than that of AA model. After a certain period of membrane formation ( 14, 28 d) , the two models had a preference for hematology, blood biochemistry and pathology indexes. At the same time, RA symptoms in rats treated with methotrexate or leflunomide showed significant efficacy in both CIA and AA models. Conclusion CIA and AA models rats showed good stability and pathological characteristics of RA. Furthermore, both CIA and AA models manifested high level evaluating abilities of drug efficacy. In conclusion, there are some differences between CIA and AA rat models of RA, such as pathological characteristics, etc. , so the use of rat model needs to be considered according to the specific research aims.

Key words: rheumatoid arthritis, rat model

摘要： 目的 探讨类风湿关节炎(RA) 动物模型对 RA 发病机制、影响因素以及治疗方法等方面的研究。 方法 分别构建风湿性关节炎 CIA 与 AA 大鼠模型,并给予临床关节炎治疗药物甲氨蝶呤和来氟米特进行干预,详细对比分析两种常用 RA 动物模型关节炎疾病特征的异同点、成模过程稳定性、可重复性以及对药物治疗效果的评价能力。结果 CIA 成膜速度比 AA 模型更早,两种模型在一定造膜周期(14、28 d)后,对血液学、血液生化学和病理学指标表标价各有偏重。 同时,在给予甲氨蝶呤或来氟米特后,大鼠 RA 症状在 CIA 和 AA 模型上均有一定程度的疗效。结论 CIA 和 AA 模型具有良好的关节炎成模性,成模后的病理指标稳定。 同时,对临床常用治疗药物的药效也具有良好的评价能力。 但两种模型的成模速度,病理特征等有一定程度差异,可根据具体研究需要进行挑选。

关键词: 风湿性关节炎, 大鼠模型